Colorado will look to make it four in a row as it turns to lefty Drew Pomeranz, while Milwaukee counters with emergency starter Marco Estrada, who is filling in for the injured Chris Narveson, sidelined with a tear to the rotator cuff in his left shoulder.
Narveson's injury created a spot for Estrada in the starting rotation, and he's comfortable with it after making seven starts in 2011.
"This is what I'm used to," said Estrada, who takes a 3.00 ERA into Saturday's start. "It's nothing new, I did it last year. Mentally, I always think like a starter, so I'm prepared to go out there and give it everything I've got."
The 28-year-old hasn't made a start since Spring Training and is among a significant group of players afflicted by an illness that has swept through the clubhouse over the past week.
"I feel fine," he said. "I don't know about pitch counts, but if I feel good enough to keep going, I'm going to tell them I'm fine. They have the last say."
Pomeranz, meanwhile, wil be looking to rebound after getting shelled by Arizona in his first outing of the season.
"I really wasn't pitching and attacking hitters with my strengths," said Pomeranz, who lasted 4 1/3 innings and gave up five runs on nine hits. "I wasn't locating all three pitches very well. I wasn't locating my fastball particularly well. Just normal things that I need to work on and fine tune."
Brewers: Willy Peralta getting called up
The Brewers expect to place reliever Kameron Loe on the bereavement list Saturday so he can attend his grandfather's funeral in California. Coming up from Triple-A Nashville is top pitching prospect Wily Peralta, a right-handed starter.
The Brewers plan to keep Estrada in the rotation and send Peralta back to Nashville when Loe returns Tuesday. That could change when more details emerge on Narveson's torn rotator cuff and the estimated recovery time becomes clear.
"Because of what Marco did last year for us, he's deserving, we feel," Brewers manager Ron Roenicke said of Saturday's start.
"If he hadn't had that experience and success at it, then we are talking about Wily Peralta making that start," Roenicke said. "It's important for [Estrada] that he knows he can pitch here as a starter."
Mat Gamel has done his best to replace Prince Fielder, who the Brewers lost as a free agent to the Detrot Tigers this past offseason.
Gamel, who hit .310 with 28 homers, 96 RBIs and a .932 OPS at Triple-A Nashville last season, is batting .298 with an .800 OPS over 14 games in 2012. He also leads all Major League first basemen with three stolen bases.
Rockies: Cuddyer banged up
Michael Cuddyer didn't start Friday's game against the Brewers because of an injured toe that was still bothering him after foulding a pitch off his foot Wednesday.
Manager Jim Tracy said before the game that Cuddyer was available off the bench if needed and that proved to be the case, as Tracy inserted him as a pinch-hitter in the ninth and he came through with a game-winning RBI single.
Cuddyer has gotten off to a hot start in his first season with Colorado. He's third in the National League in batting at .383, third with a .702 slugging percentage, and fourth with a 1.110 OPS.
Troy Tulowitzki was back in the lineup Friday after getting a day off for Wednesday's series finale against the Padres.
The All-Star shortstop has been struggling both offensively and defensively to start the season, and admitted that an uncharacteristic six errors already has been getting to him mentally. The six errors match the total Tulowitzki had during his second consecutive gold-glove season last year.
Rockies manager Jim Tracy chose to not make a big deal of the situation and Tulowitzki responded by going 2-for-4 with a RBI double in Friday's win over Milwaukee.
Chris Toman is an associate reporter for MLB.com.