After taking Tuesday's game, 9-6, the Twins will look to finish their perfect season vs. the Astros in Wednesday's series finale at Minute Maid Park.
Minnesota is 5-0 against Houston this season as it continues to dominate the American League West despite being 15 games below .500 on the year.
The Twins are 17-7 against the West, but just 44-69 against the rest of the Majors.
Looking to finish the season sweep will be starter Liam Hendriks, who will be making just his sixth start of the season.
The 24-year-old has effectively carved up hitters throughout his Minor League career, but continues to struggle with batters at the highest level.
In 100 games in the Minors, 98 of them starts, Hendriks has a 42-28 record and a 2.99 ERA, however, he's 2-12 with a 5.60 ERA in 25 starts in the Majors.
When he last toed the rubber against the Rangers however, he was able to best Yu Darvish.
The Twins right-hander allowed two runs (one earned), on five hits, three walks, with a pair of strikeouts in six innings on the mound to pick up his second career victory.
He'll be up against a comparable veteran in 22-year-old Jordan Lyles, who will be making his 62nd start of his career.
Lyles made his Major League debut back in 2011 against the Cubs at the ripe age of 20. Since then he's thrown over 350 innings, almost exclusively as a starter, and continues to show glimpses of why the Astros were so high on him two years ago.
Despite a MLB career ERA of 5.17, the young right-hander is 2-1 with a 3.54 ERA over his last three starts, and is still the youngest pitcher in the American League who has tossed at least 100 innings this season.
Last time out against the Mariners, Lyles picked up a quality start, but lowered his record to 6-7 thanks to a pair of home runs that accounted for all three of the Seattle runs.
"I thought he battled," Astros manager Bo Porter said. "He left a couple of pitches up that those guys put good swings on and ended up being the deciding factor in the game, the solo homer and the two-run homer. I felt like he battled and did a good of job of when he left the game we were still in a position to possibly win the ballgame."
Astros: Houston acquires catching depth in Pagnozzi
A day after Jason Castro left the game with a right knee injury the Astros made a deal to acquire Triple-A catcher Matt Pagnozzi.
Pagnozzi was obtained from the Braves in exchange for cash considerations.
The 30-year-old has spent the majority of his time in the Minor Leagues, but has appeared in 34 games in the Majors with four different teams. In those games he's batted .306 with one home run and 13 RBIs, but hadn't appeared in the big leagues since 2011 until Tuesday's pinch-hit groundout to end the game.
"It's very exciting," Pagnozzi said, who just wrapped his season with Triple-A Gwinnett. "Any time you can be a part of something like this, especially getting another month of playing baseball, I'm looking forward to it."
Although Castro is deemed day to day with a cyst on the medial side, without this acquisition the Astros had only one healthy catcher on their 40 man roster with both Carlos Corporan and Max Stassi also injured.
"I'm glad we were able to get someone for no other reason than the health issues that have been going on with our catchers," Porter said.
Twins: Arcia returns to lineup fully healthy
Minnesota right fielder Oswaldo Arcia returned to the starting lineup in Tuesday's 4-1 victory over the Astros, going 0-for-3 batting seventh in the lineup.
Arcia had only started one game since bruising his left wrist on Aug. 19 while diving for a fly ball, but was finally ready to get back into the lineup on Tuesday.
"I was told [on Monday] that he was feeling great," manager Ron Gardenhire said. "He's been telling me he's ready to go for three days -- ready to pinch-hit, ready to play.
"We've waited and waited and waited [for his return]."
Arcia is hitting .251 with 10 homers, third most among American League rookies, and has driven in 32 in 78 games. He put together a career high nine-game hitting streak just prior to the injury.
• Lyles is the longest tenured starting pitcher on the Astros pitching staff despite being 22-years-old. He will be making his 22nd start of the season and the 62nd of his career Wednesday. Dallas Keuchel, 25, would be second with 34 starts and 43 appearances in his career.
Evan Peaslee is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.