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6/14/2014 3:20 A.M. ET

Tulo leaves game in ninth with right toe injury

Shortstop replaced after hitting a single to start game-winning rally

SAN FRANCISCO -- Rockies shortstop Troy Tulowitzki departed Friday night's 7-4 victory over the Giants with a right toe injury after leading off the top of the ninth inning with a single. X-rays on the third metatarsal on the right foot were negative.

"Right now, it looks like a sprained toe," manager Walt Weiss said. "He felt something in his foot, and that's what we're calling it right now."

Beyond the injury and the X-rays, the Rockies had no information on how much time Tulowitzki could miss, or whether he would miss games. The club's regular batting order currently is without left fielder Carlos Gonzalez (benign tumor in left index finger), right fielder Michael Cuddyer (fractured left shoulder) and third baseman Nolan Arenado (broken left middle finger).

With the Rockies trailing by two runs and Giants closer Sergio Romo pitching, Tulowitzki singled into center field, but he pulled up as he reached first base. The hit started a game-winning rally.

Charlie Culberson replaced him and scored on Ryan Wheeler's two-run, bases-loaded single that tied the game at 4. DJ LeMahieu's single to center drove in the go-ahead run. Michael McKenry added an RBI single, and LeMahieu scored when McKenry was picked off first base.

Tulowitzki -- who entered the game leading the Majors in hitting (.356), on-base percentage (.488), slugging (.667) and OPS, or on-base percentage plus slugging percentage (1.115) -- went 1-for-3 with a walk. Tulowitzki also came into the week leading all National League players in All-Star fan voting. He is seeking his second straight fan-elected start.

The Rockies have been careful with Tulowitzki's health the last couple of seasons, and he has not experienced the long-term leg muscle injuries that have kept him off the field in the past. They've given him days off from the starting lineup on occasion in an attempt to stave off muscle injuries.

But the strategy doesn't prevent all injuries. Last year, Tulwotizki missed 25 games after he dove for a ground ball June 13 -- a year to the day ago -- and suffered a broken rib on the right side.

Thomas Harding is a reporter for MLB.com. Read his blog, Hardball in the Rockies, and follow him on Twitter @harding_at_mlb. This story was not subject to the approval of Major League Baseball or its clubs.